Cutaneous Changes During the Menstrual Cycle: A Clinical and Experimental Study Under Physiological Condition and After Therapy

1956 
In recent years, much clinical interest has centered on the cyclic variations that characterize menstrual activity. Particular attention has been focused on the so-called premenstrual "tension state," which is characterized by a number of symptoms, including anxiety and depression or irritability and restlessness, insomnia, vertigo, marked changes in thirst, appetite, and sexual desire, pain and swelling of the breasts, abdominal bloating, backache, leg cramps, asthmatic episodes, and migraine and other types of headaches. * As is well known, these symptoms progressively increase in severity during the week to 10 days preceding the menstrual flow, only to greatly diminish in severity or to disappear with the onset of the menses. Concomitantly, physicians have often observed a moderate degree of fluid retention demonstrable by a variable weight gain and, on occasion, manifest as clinical edema. On the premise that some of the disturbances characteristic of premenstrual
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