Optimal fitting of computer model simulations to first transit cardiac radionuclide curves. II

For pt.I see ibid., vol.36, no.9, p.935-45 (1989). A discrete-time, lumped-parameter mathematical model of the human cardiopulmonary circulation as it appears during a first-transit radionuclide study was described in pt.I. An optimal fitting process is used to match curves obtained from the model to curves obtained from first transit studies in order to estimate the parameters of the subject's heart. The development of the optimization technique is described. The results of testing the effects of overlapping compartments and errors in delay estimates are presented. A parameter determination analysis is performed by applying the optimization algorithm to simulated data. This analysis technique provides a method of estimating many parameters of heart function using a single, simple, rapid procedure. >