A sensitive and selective spectrophotometric method for 2-chlorophenol based on solid phase extraction with mixed hemimicelle magnetic nanoparticles

Abstract The first study of a sensitive and selective spectrophotometric detection of 2-chlorophenol (2-CP) was reported. The method is based on derivatization of 2-CP with 4-aminoantipyrine (4-AAP) and subsequent preconcentration by solid phase extraction (SPE) using mixed hemimicelles adsorbent of cetyltrimethylammonium bromide coated magnetic nanoparticles (CTAB coated Fe 3 O 4 NPs) before its detection by spectrophotometry at 510 nm. The adsorption capacity was evaluated using the Langmuir adsorption isotherm model, with high correlation coefficients ( R 2  = 0.9983). The optimum conditions for SPE were CTAB coated Fe 3 O 4 NPs 20 mg under vortex 60 s and methanol as the desorption solvent under sonication for 7 min. The linearity of the method was in the range of 0.05–1.0 mg L −1 with correlation coefficient (0.9970). The limit of detection (LOD) and limit of quantitation (LOQ) were 0.01 mg L −1 and 0.05 mg L −1 , respectively. Good precision with relative standard deviation (%RSD, n  = 5) less than 3.7% was obtained. The method was successfully applied for the determination of 2-CP in soil samples with satisfactory recoveries (81.7–95.2%).