Pirrolidylthiocarbapenem glass derivative, lyophilized preparation containing said glass and process for its production.

The present invention provides a crystal of (1R, 5S, 6S) -6 [(1R) -1-hydroxyethyl] -2 - [(3S, 5S) -5-SULFANOAMINOMETIL1-pyrrolidin-3-yl] thio-1- methyl-1-CARBA-2-penem-3-carboxylic acid represented by the following formula, A lyophilized preparation comprising the crystal, and a method for producing it. UNDERSTAND THE PRODUCTION PROCESS PHASE AQUEOUS SOLUTION FREEZING CONTAINING THE COMPOUND ABOVE, cooling to -20 LOWER CO; Heat the solution chilled to 0 -10 C O; AND CHILL AND FROZEN heat the solution at least twice in a range of temperatures from 0 to -10 C.