Гипоксический синдром у детей с кардиопатиями

The National research center "Kurchatov Institute', Moscow, Russia The children with inherited cardiopathy including hypersensitive (n=85) and dilatation (n=10) cardiopathy as well as cardiopathy under Ehlers-Danlos Syndrome (n=70) combined with different inherited heart disease were examined to establish signs of hematic and tissue hypoxia. The most typical signs turned out periodic decrease of blood pCO2 with increasing of content of lactate and pyruvate in blood and saliva, multiple caries of teeth and high rate of systemic hypoplasia of enamel of both temporary and permanent teeth. The study established decrease in blood of level of macro-ergic compounds (ATP, ADF, AMP) with increasing of excretion calcium andphosphates with urine. The increase of rate ofmutations of hypoxanthine guanine phosphoribosyltransferase in lymphocytes with increasing of content of uric acid in blood and/or in urine was detected. The study revealed increasing of processes ofperoxide oxidation, alterations of morphology of cells of skeletal muscles (RRF) and accumulation of calcium, lipids and alteration of structure of mitochondria.