A Straightforward Synthesis of Alkyl 1H-Tetrazol-5-yl Thioethers via a One-Pot Reaction of Aldehydes and 1H-Tetrazole-5-thiols Mediated by N-Tosylhydrazones.
2015
A straightforward approach for the synthesis of alkyl 1H-tetrazol-5-yl thioethers from aldehydes and 1H-tetrazole-5-thiol through a one-pot procedure is presented. The aldehydes were first condensed with N-tosylhydrazine to generate the N-tosylhydrazones, which were then reductively coupled in situ with 1H-tetrazole-5-thiols under metal-free conditions to afford the thioethers in high to excellent yields.
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