"A study of the risk factors for post transplant erythrocytosis at Sina and Baghiat – Allah Hospital"
2006
Background: Post-transplant erythrocytosis (PTE) is characterized by persistent
hematocrit level above 51% that develops in 10-20% of kidney recipients, mostly 2
years after kidney transplantation. PTE is self limited in 25% of the patients but can be
persistent in other patients with an increased susceptibility for thrombosis. The purpose
of this study was to identify the risk factors for development of PTE in our center
Methods: We selected 45 patients who were transplanted at least 3 months before
selection (minimum time required for detection of PTE) and were referred to the
kidney transplantation clinic during 5 years (1998-2003) as the case group. At the same
time, we considered 2 patients without erythrocytosis as control for each patient in the
case group among kidney transplant recipients who were referred to the same clinic
during 5 years (1998-2003).
In total we had selected 135 patients, 45 patients with erythrocytosis as the case group
and 90 patients without erythrocytosis as the control group. Patients who were affected
by high hematocrit before transplantation (HC>51%),overt pulmonary disorder, and
polycytemia Vera were excluded from this study.
We collected basic information by using old charts and complementary information
was added through phone conversations and physical examination in the clinic. All the
information was entered in the digital questionnaire and was analyzed by the SPSS
statistical package.
Results: There was no significant difference between the case and control group for
age, history of hypertension, diabetes, pretransplant hematocrit, pretransplant
transfusions, function of graft and source of kidney. A significantly higher proportion
of PTE patients were male, also the case group had a significantly higher frequency for
personal history of polycystic kidney disease , glomerulonephritis and higher frequency
of azathioparine, prednisolone and cyclosporine regimen.
Conclusion: PTE is an important complication of kidney transplantation that can be
fatal. There are multiple risk factors that should be addressed to prevent this
complication.
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