Changes in the levels of glycolysis and tricarboxylic acid cycle metabolites in cat tissues during periodontosis

: The predominance of restored substrates in the bone system and liver of cats under chronic parodontosis evidence for intensification of reproduction properties of NAD-pairs and causes inhibition of glycolysis and activation of gluconeogenesis. A high content of alpha-ketoglutarate and isocitrate in tissues in a result of lipogenesis inhibition. Under the lower rate of glycolysis, activation of proteolysis and transamination reactions amino acids are the major contributors to pyruvate. Under the acute course of the disease with the development of the inflammatory process the quantity of pyruvate grows sharply in the parodont tissue, as well as oxidative properties of NAD-pairs intensify and lipogenesis accelerates. This is confirmed by a decrease in the alpha-ketoglutarate and isocitrate content in the tissues.