A case of acquired hemophilia detected after influenza vaccination

Acquired hemophilia is a rare disorder associated with development of factor VIII inhibitors. Acquired inhibitors against factor VIII in nonhemophilic patients are associated with various conditions, including autoimmune diseases, malignancies, the postpartum state, drug reactions. In this report, we described the case of a 65 year-old female, who developed generalizd petechiae and gross hematuria due to the appearance of inhibitors against factor VIII following influenza vaccination. She was treated with steroid and cyclophosphamide but retroperitoneal hemorrhage developed, and she died.