Effect of Primary and Delayed PCI on Heart Function of Patients with AMI

Objective:To investigate the effect of primary and delayed PCI on plasma BNP in patients with AMI by a series measurements of BNP at different time before and after PCI.Methods:Consecutive 45 patients with STEMI who were hospitalized in cardiovascular department of the Third Hospital of Hebei Medical University from December 2005 to November 2006 were eligible,All samples collected on admission immediately,7 days and 30 days after PCI were performed by enzyme-linked immunosorbent assay(ELISA).Results: 1 There was no significant difference of plasma BNP between two groups pre-PCI.2 Two groups plasma BNP concentration after PCI both decreased compared with that of pre-PCI,there was significant difference on 7 days(P0.05)and the difference was more obvious on 30 days(P0.01)after PCI.BNP remained significant lower in Group A than Group B after PCI 7 days(183.4±56.2pg/mL vs 243.7±85.2pg/mL P0.05),more significant difference was showed after PCI 30 days(108.3±36.7pg/mL vs 139.4±76.8pg/mL P0.05)between two groups.Conclusion:Plasma BNP concentration in patients with AMI was decreased after reperfusion therapy of PCI,but effect of primary and delayed PCI on AMI was distinct,the former was decreased faster and more obviously than the latter,and primary PCI outstripped delayed PCI.