Ti-catalyzed reactions of unsymmetrical alkynes with esters of monocarboxylic acids and EtAlCl2: An efficient catalytic method for the synthesis of tetrasubstituted furans

Abstract A new one-pot synthesis of tetrasubstituted furans by the reaction between unsymmetrical alkynes and esters of carboxylic acids in the presence of EtAlCl 2 and Cp 2 TiCl 2 catalyst has been developed. The effect of the unsymmetrical alkyne substituent on the chemoselectivity of the reaction was studied.