Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes

Abstract We investigated whether serum levels of N -(carboxymethyl)lysine (CML), non-CML advanced glycation endproducts (AGEs), or pentosidine are associated with severity of diabetic microvascular complications in patients with Type 1 diabetes. Serum levels of CML, non-CML AGE, and pentosidine were measured by an enzyme-linked immunosorbent assay in 38 males and 47 females aged 31±8 years (mean±S.D.) with Type 1 diabetes for 18.7±7.0 years. There was a significant correlation between serum levels of CML or non-CML AGE and current HbA 1c level ( P P P P P P