Towards reperfusion-centric preclinical stroke research：outside the box of “reperfusion injury”

Stroke is a major health issue of increasing significance for any society with an aging population.Globally,stroke is the second-leading cause of death with approximately5.9 million fatal events in 2010,equivalent to 11.1%of all deaths.Yet,despite years of preclinical research on neuroprotection and a multitude of clinical trials,tissue plasminogen activator(tPA)-mediated recanalization remains