FRI0243 Extent of disease on high-resolution CT lung is a predictor of decline and mortality in systemic sclerosis-related interstitial lung disease
2013
Objectives We sought to determine whether the extent of disease on high-resolution CT lung (HRCT), measured using a simple grading system,[1] is predictive of decline and mortality in systemic sclerosis-related interstitial lung disease (SSc-ILD), independently of pulmonary function tests (PFTs) and other prognostic variables. Methods SSc patients with a baseline HRCT performed at the time of ILD diagnosis were identified. All PFTs performed during follow-up were retrieved. Demographic and disease-related data were prospectively collected. HRCTs were graded according to the percentage of lung disease seen; >20% - extensive, Results Among 172 patients followed for mean±SD of 3.47±2.93 years, there were 33 outcome events. Figure 1 shows a Kaplan-Meier survival curve of HRCT score against survival. Survival estimates were significant for two raters and approached significance for the third (log-rank p Conclusions Extensive changes (>20%) on HRCT at baseline, reported using a semi-quantitative grading system, are associated with a three-fold increased risk of deterioration or death in SSc-ILD, compared with limited changes. References Goh NSL, Desai SR, Veeraraghavan S, et al. Interstitial Lung Disease in Systemic Sclerosis: A Simple Staging System. American Journal of Respiratory and Critical Care Medicine 2008;177:1248–1254. Disclosure of Interest None Declared
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