Phthalate and Bisphenol Urinary Concentrations, Body Fat Measures, and Cardiovascular Risk Factors in Dutch School-Age Children.
2021
Objective: The purpose of this study was to investigate the associations
of urinary phthalates and bisphenols at age 6 years old with body fat and
cardiovascular risk factors at 6 and 10 years and with the change from
6 to 10 years.
Methods: Among 471 Dutch children, the phthalates and bisphenols urinary concentrations at 6 years and BMI, fat mass index, android fat mass,
blood pressure, glucose, insulin, and lipids blood concentrations at 6 and
10 years were measured.
Results: An interquartile range increase in di-n-octyl phthalate (DNOP)
metabolites concentrations at 6 years was associated with an increased
risk of overweight at 6 and 10 years (odds ratio: 1.44; 95% CI: 1.11-1.87,
and 1.43; 95% CI: 1.09-1.86, respectively). Also, higher DNOP metabolites concentrations were associated with higher fat mass index at
6 years, higher systolic blood pressure at 10 years, a decrease in highdensity lipoprotein cholesterol, and an increase in triglycerides concentrations from 6 to 10 years (P<0.05). Higher total bisphenols and bisphenol
A concentrations were associated with a decrease in BMI from 6 to
10 years (P<0.01).
Conclusions: DNOP metabolites are associated with overweight and
an adverse cardiovascular profile in childhood. Total bisphenols and
bisphenol A are associated with a decrease in BMI from 6 to 10 years.
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