N-(4-芳醯胺基苯基)甲磺醯胺類化合物的合成及抗炎活性
2004
Aim To study the anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives. Methods The target compounds were synthesized from p-nitroaniline via three steps and were evalnated for anti-inflammatory activity with the model of xylene-induced ear edema in mice. Results Eleven compounds were obtained and confirmed by JR, 1 HNMR and MS. Some compounds were shown to have significant anti-inflammatory activity. Conclusiou N-(4-arylamidophenyl) methanesulfonamide showed appreciable anti-inflammatory activity.
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