One-Pot Two Step Synthesis of 5-Cyano-dihydropyrimidinones Using Polyphosphate Ester.

Robert J. Schmidt,Louis J. Lombardo,Sarah C. Traeger,David K. Williams

One-Pot Two Step Synthesis of 5-Cyano-dihydropyrimidinones Using Polyphosphate Ester.

2008

Robert J. Schmidt
Louis J. Lombardo
Sarah C. Traeger
David K. Williams

Abstract A combination of a modified Biginelli reaction and a polyphosphate ester (PPE)-promoted dehydration reaction provides 5-cyano-dihydropyrimidinones in good to excellent overall yields.

Keywords:

Polyphosphate
Chemistry
Organic chemistry
two step

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