Temperature-dependent optical properties of Intralipid ® measured with frequency-domain photon- migration spectroscopy

We present the temperature dependence of absorption and reduced scattering coefficients of 1.8% Intralipid measured by frequency-domain photon-migration spectroscopy between 710 and 850 nm. These measurements were made in the physiologically rel- evant 30 to 40°C temperature range. The temperature coefficients for absorption were consistent during heating and cooling and follow closely other reported results. The change in absorption coefficient at 740 nm suggests that a minimum temperature change of 4°C is ob- servable within the error limits. We found that the reduced scattering coefficient shows a hysteresis with temperature at 740 nm. The tem- perature coefficient for reduced scattering determined from heating cycle measurements agrees with theory and other measurements within the error limits. © 2010 Society of Photo-Optical Instrumentation Engineers. DOI: 10.1117/1.3290820