Endoplasmic Reticulum Stress Sensor IRE1α Regulates Oxidative Proinsulin Folding: Cooperation of the Five Specific Protein Disulfide Isomerases Is Required for Proinsulin Folding: プロインスリンの折り畳みには5種類のジスルフィド結合形成酵素の共同作業が必要