Therapeutic efficacy of compound matrine injection combined with Fentanyl transdermal patch on cancer pain in elderly patients with advanced gastric cancer

Objective To evaluate the clinical efficacy of compound matrine injection combined with fentanyl transdermal patch in the treatment of elderly patients with advanced gastric cancer. Methods A total of 100 elderly patients with advanced gastric cancer were enrolled in this study.All patients were randomly divided into the observation group(n=50)given compound matrine injection plus Fentanyl transdermal patch and the control group given fentanyl transdermal patch alone(n=50). The analgesic efficacy, quality of life and adverse reaction were evaluated and compared between the two groups. Results The analgesic efficacy was significantly higher in the observation group[76%(38/50)]than in the control group[(44%), (χ2=4.46, P 0.05). Conclusions Compound matrine injection plus Fentanyl transdermal patch are safe and effective in the treatment of carcinoma pain in elderly patients with advanced gastric cancer. Key words: Matrine; Fentanyl; Advanced gastric cancer; Carcinoma pain