5-HT2C receptor agonists with potential anorectic activity

Substituted 2,3,4,4a-tetrahydropyrazino[2,1-c][1,4]benzoxazin-5-(1H)-ones were synthesized and evaluated as 5-HT2C receptor agonists for the possible treatment of obesity. A number of compounds exhibited 5-HT2C agonist binding activity with compound 19 showing the most potent in vitro activity.