Dimethyldichlorosilane – an Effective Reagent for One-Step Synthesis of \( \boldsymbol{\upalpha} \)-Amino Acid Amides

A preparative method for a one-step synthesis of amino acid amides was developed using dimethyldichlorosilane. This method produces amides with yields ranging from 45% to 89% and purity greater than 95%. Neither racemization nor inversion of the configuration of the asymmetrical center in the starting α-amino acid occurs during the reaction.