Reactions of Substituted 5-Nitro-3-furoylthioureas

Some cyclization and cyclocondensation reactions of 1-(5-nitro-3-furoyl)-3-(4-R-phenyl)thioureas 1a - 1e (R = H, CH 3 , N(C 2 H 5 ) 2 , Br, CN) were conducted. 6-R-2-(5-Nitro-3-furoylamino)benzothiazoles 2a - 2c (R = H, CH 3 , Br) were obtained by bromine-induced cyclization of the corresponding thioureas. Reacted with bromoacetone and ω-bromoacetophenone, respectively, the derivatives 1a-1e gave 2-(4-R-phenylimino)-3-(5-nitro-3-furoyl)-4-R 1 -4-thiazolines 3a-3e (R = H, CH 3 , N(C 2 H 5 ) 2 , Br, CN; R 1 = CH 3 ) and 3f-3j (R = H, CH 3 , N(C 2 H 5 ) 2 , Br, CN; R 1 = C 6 H 5 ), respectively. The structure of the compounds synthesized was confirmed by IR, UV, 1 H NMR and MS data.