Diagnosis and treatment of NSAIDs induced colonic mucosal lesions

: NSAIDs induced colonic mucosal lesions have been reported to be found in about 3% of chronic NSAIDs users in Japan, suggesting that a particular attention should be paid for the clinical management of NSAIDs users. Differential diagnosis of these lesions is considered to be difficult only by the morphological examination since endoscopic images of the lesions show very various types such as ulcerative and colitis type. Therefore, the diagnostic criteria proposed by Iida et al. play an important role for the confirmation of the clinical diagnosis. Treatment for the lesions is principally the discontinuation of NSAIDs administration since many possibly agents have not been fully evidenced the effect by clinical cohort study. The establishment of the guideline for clinical management of patients with NSAIDs induced colonic mucosal lesions is sincerely required.