Expression of STAT5 and VEGF in NSCLC and their correlation

Objective To examine the expression of STAT5 and VEGF in NSCLC and to study their relationship.Methods STAT5 and VEGF proteins were detected in formalin-fixed paraffin-embedded tissue from 68 non-small cell lung cancer tissues and 26 normal lung tissues by SP immunohistochemical method.The levels of their expression and their relationship with STAT5 and VEGF were analyzed.Results The positive rates of STAT5 and VEGF in NSCLC were dramatically higher than that in the normal lung tissues(P0.05);The expression of STAT5 were significantly correlated with histological types of NSCLC(P0.01),and were higher in adenocarcinomas than in squamous carcinomas;The expression of VEGF were significantly correlated with histological grading,TNM stage and lymph node metastasis,but were not correlated with the histological types of NSCLC(P0.05).There was significantly positive association between STAT5 and VEGF.Conclusion The high expression of STAT5 and VEGF in NSCLC plays important role in occurrence,invasion and metastasis of NSCLC.The inhibition of STAT5 signal access may become a targets for cancer therapy.