Pirimidilsulfonamida derivatives as modulators of chemokine receptor

A compound of formula (1), a pharmaceutically acceptable salt or solvate thereof: ** ** Formuna wherein R1 is a group selected from C3-7 carbocyclyl [wherein a -CH2- group can optionally estarsustituido for -C (O) -], C1-8alkyl, C2-6 aquenilo and C2-6 alkynyl; wherein the group is opcionalmentesustituido with 1, 2 or 3 substituents independently fluoro, nitrile, -OR4, -NR5R6, -CONR5R6, -COOR7, -NR8COR9, -SR10, -SO2R10, -SO2NR5R6, -NR8SO2R9, phenyl or selected heteroaryl; wherein phenyl and heteroariloestan optionally substituted with 1, 2 or 3 independently selected from halo, cyano, nitro, -OR4, -NR5R6, -CONR5R6, -COOR7, -NR8COR9, -SR10, -SO2R10, -SO2NR5R6 substituents selected -NR8SO2R9 , C1-6alkyl ytrifluorometilo.