Macrophage phenotype in sepsis immunosuppression
2015
Sepsis is followed by profound, yet poorly characterized, innate immune system suppression. While low monocyte HLA-DR expression is observed in septic patients, its clinical significance has not been established [1]. In vitro, repeated LPS stimulation induces a tolerant or M2 macrophage phenotype, characterized by decreased cytokine production [2], which could contribute to sepsis immunosuppression. The present study examines macrophage phenotype in a mouse model and in patients with sepsis immunosuppression.
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