Self-referenced silicon nitride array microring biosensor for toxin detection using glycans at visible wavelength
2013
We report on application of on-chip referencing to improve the limit-of-detection (LOD) in compact silicon nitride
(SiN) microring arrays. Microring resonators, fabricated by e-beam lithography and fluorine-based etching, are
designed for visible wavelengths (656nm) and have a footprint of 20 x 20 μm. GM1 ganglioside is used as the
specific ligand for recognition of Cholera Toxin Subunit B (CTB), with Ricinus Communis Agglutinin I (RCA
I) as a negative control. Using micro-cantilever based printing less than 10 pL of glycan solution is consumed
per microring. Real-time data on analyte binding is extracted from the shifts in resonance wavelengths of the
microrings.
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