Clinical and biological significance of chromosome disorders in acute leukemia in children

: Chromosomal examination was made in the bone marrow and lymphocytes of the peripheral blood of 37 children with acute leukemia. Of them 25 had acute lymphoblastic leukemia (ALL), 12 had acute nonlymphoblastic leukemia (ANLL). NA karyotype was registered in 13 patients (5 with ALL, 9 with ANLL), AA karyotype in 17 children (12 with ALL, 5 with ANLL). In All the following chromosomal markers were identified: del(6)/(q22), del(7)(q32), del(11)(q23), 9p+, t(8; 14) (q24; q32). In ANLL there were: 46, XY, t(3; 8)/46, XY; 47, XY, +16, +(2; 14)--M1-form; 46, XX, t(8; 21); 46, XX, t(8; 21)/46, XX--M2-form; 47, XX, +mar/46, XX; 47, XY, +12--M4-form; 46, XX, del(16)/46, XX, 47, XY, +16; 48, XY, +5, +8--M5-form FAB.