Method for detecting toxicity of cefazedone sodium impurities and intermediates

The invention relates to a method for detecting toxicity of cefazedone sodium impurities. TU line Zebra fish, Danio rerio Tuebingen serves as a model animal of pharmocotoxicology evaluation. The invention relates to toxicity evaluation of intermediate impurities, byproducts and various degraded impurities of cefazedone sodium in the whole synthetic process. The toxicity of trace impurities in cefazedone is evaluated by chiefly adopting a novel model animal 'zebra fish' of the pharmocotoxicology evaluation, the product quality can be effectively controlled through a zebra fish toxicity test, the safety of clinical use is guaranteed, and a reliable basis is provided for administration safety of a patient.