Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

V.K. Schulze,Ulrich Klar,Dirk Kosemund,Antje Margret Wengner,Gerhard Siemeister,Detlef Stöckigt,Roland Neuhaus,Philip Lienau,Benjamin Bader,Stefan Prechtl,S.J. Holton,Hans Briem,Tobias Marquardt,Hartmut Schirok,Rolf Jautelat,Rolf Bohlmann,Duy Nguyen,Amaury E. Fernández-Montalván,Ulf Bömer,Uwe Eberspaecher,Michael Dr. Brüning,Olaf Döhr,Marian Raschke,Bertolt Kreft,Dominik Mumberg,Karl Ziegelbauer,Michael Brands,Franz von Nussbaum,Marcus Koppitz

Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

2020

Inhibition of monopolar spindle 1 (MPS1) kinase represents a novel approach to cancer treatment: instead of arresting the cell cycle in tumor cells, cells are driven into mitosis irrespective of DN...

Keywords:

Spindle checkpoint
cancer treatment
monopolar spindle
tumor cells
Cancer
Cancer research
Kinase
Biochemistry
Chemistry
Mitosis
Cell cycle

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