Bioactive secondary metabolites from the marine-associated fungus Aspergillus terreus

Abstract Three new compounds, including a prenylated tryptophan derivative, luteoride E ( 1 ), a butenolide derivative, versicolactone G ( 2 ), and a linear aliphatic alcohol, (3 E ,7 E )-4,8-dimethyl-undecane-3,7-diene-1,11-diol ( 3 ), together with nine known compounds ( 4 – 12 ), were isolated and identified from a coral-associated fungus Aspergillus terreus . Their structures were elucidated by HRESIMS, one- and two-dimensional NMR analysis, and the absolute configuration of 2 was determined by comparison of its electronic circular dichroism (ECD) spectrum with the literature. Structurally, compound 1 featured an unusual ( E )-oxime group, which occurred rarely in natural products. Compounds 1 – 3 were evaluated for the α -glucosidase inhibitory activity, and compound 2 showed potent inhibitory potency with IC 50 value of 104.8 ± 9.5 μM, which was lower than the positive control acarbose (IC 50  = 154.7 ± 8.1 µM). Additionally, all the isolated compounds were evaluated for the anti-inflammatory activity against NO production, and compounds 1 – 3 , 5 – 7 , and 10 showed significant inhibitory potency with IC 50 values ranging from 5.48 to 29.34 μM.