Diagnosis and treatment of vasoactive intestinal peptide tumors:one case report and literature review in China

Objective this paper summarizes the clinical data of twenty five patients of VIPoma to explore the methods of diagnosis and treatment of the VIPoma. Methods there has been one VIPoma patient received and cured in our hospital in 2010, February and the author searched other twenty four patients from literature documents from January of 1993 to December of 2009. And then this paper makes analysis according to these 25 clinical expressions, laboratory examinations, image detection ,the methods of operation and the follow-up data. Results there were 22 out of the 24 examples developing watery diarrhea documented happened periodically;22 cases' serum potassium had been detected, and among them, 21 cases have the hypokalemia. 13 cases' blood plasma VIP measuered higher than normal.CT checked 22 cases and 18 ones of them had lisions, and 7 ones had liver metastasis. Among the 25 cases, 24 cases had accepted surgical treatment. In the 13 resections of the tail of the pancreas, 8 ones got long-term follow-up visits, for 3～3.5 years: one case died because of the massive haemorrhage, one case had the recurrence and hepatic metastases after 3.5 years, but the other 6 cases didn't have the recurrences. Conclusion the diagnosis of VIPoma relies on typical clinical symptoms and bloodplasma VIP measurement;B-type ultrasonic and CT are the reliable diagnosis methods of VIPoma .Surgical excision is an effective treatment of the VIPoma, even the palliative resection also can improve the quality of life of patients and prolong their life.