BLINK: bit-sparse LSTM inference kernel enabling efficient calcium trace extraction for neurofeedback devices

Miniaturized fluorescent calcium imaging microscopes are widely used for monitoring the activity of a large population of neurons in freely behaving animals in vivo. Conventional calcium image analyses extract calcium traces by iterative and bulk image processing and they are hard to meet the power and latency requirements for neurofeedback devices. In this paper, we propose the calcium image processing pipeline based on a bit-sparse long short-term memory (LSTM) inference kernel (BLINK) for efficient calcium trace extraction. It largely reduces the power and latency while remaining the trace extraction accuracy. We implemented the customized pipeline on the Ultra96 platform. It can extract calcium traces from up to 1024 cells with sub-ms latency on a single FPGA device. We designed the BLINK circuits in a 28-nm technology. Evaluation shows that the proposed bit-sparse representation can reduce the circuit area by 38.7% and save the power consumption by 38.4% without accuracy loss. The BLINK circuits achieve 410 pJ/inference, which has 6293x and 52.4x gains in energy efficiency compared to the evaluation on the high performance CPU and GPU, respectively.