Экспрессия генов раково-тестикулярных антигенов в первичной меланоме кожи человека

Gene expression of 13 cancer/testis antigens, 4 melanocytic melanoma differentiation antigens and 14 melanoma markers was analyzed with respect to to mitotic index of primary melanoma cells by RT-PCR in 26 human primary melanoma specimens. Basing of expression of 32 genes all patients were divided into 3 groups of low 5-year survival, high 5-year survival with a large fraction of patients having metastatic disease, and apparently disease-free patients. Expression of the selected genes can be used as independent, highly specific and sensitive test for prognosis of survival and disease metastatic potential in patients undergoing surgery.