Advances in Tau-mediated neurodegeneration and Tau-focused drug for Alzhehimer's disease

Alzheimer's disease is the main form of dementia in today's ageing population.Aggregation of abnormally phosphorylated Tau in the form of tangs of paired helical filaments(PHFs) is one of the hallmarks of Alzheimer's disease.In Alzheimer's disease,misfolded Tau is probably a key pathological agent.The recent failure of amyloid-β-targeted therapeutics in clinical trials suggests that it is timely and prudent to consider alternative drug discovery strategies.Here,we focus on advances in Tau-mediated neurodegeneration and Tau-focused drug for Alzhehimer's disease.