TRABAJOS ORIGINALES RESPUESTA DE INSULINA A LA CARGA ORAL DE GLUCOSA EN NIÑOS Y ADOLESCENTES CON SOBREPESO Y OBESIDAD
2011
Objectives: To evaluate the insulin response to an oral glucose load in children and adolescents with overweight and obesity. Methods: Two-hundred subjects attending the out-patient endocrinology clinic of the Hospital JM de Los Rios, Caracas, Venezuela, with unspecific symptoms of hypoglycemia or body weight excess were selected. Hypoglycemia and/or carbohydrate metabolism abnormalities were ruled out. Subjects were categorized according pubertal stage and body mass index (BMI); Group A: pre-pubertal: (Tanner I), BMI P90; Group D: adolescents (Tanner II-V), BMI> P90. Plasma glucose and insulin were measured at baseline and 30, 60 and 120 minutes after oral glucose load (1.75 g/kg). Results: Basal insulin was significantly higher in adolescents and groups with abnormal body weight,
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