Genetic Variants Associated With Plasma Lipids Are Associated With the Lipid Response to Niacin

Background Niacin is a broad‐spectrum lipid‐modulating drug, but its mechanism of action is unclear. Genome‐wide association studies have identified multiple loci associated with blood lipid levels and lipoprotein (a). It is unknown whether these loci modulate response to niacin. Methods and Results Using data from the AIM‐HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial (n=2054 genotyped participants), we determined whether genetic variations at validated loci were associated with a differential change in plasma lipids and lipoprotein (a) 1 year after randomization to either statin+placebo or statin+niacin in a variant‐treatment interaction model. Nominally significant interactions (P<0.05) were found for genetic variants in MVK, LIPC, PABPC4, AMPD3 with change in high‐density lipoprotein cholesterol; SPTLC3 with change in low‐density lipoprotein cholesterol; TOM1 with change in total cholesterol; PDXDC1 and CYP26A1 with...