PHYTOCHEMICAL EVALUATION AND HEPATOPROTECTIVE ACTIVITY OF FRESH JUICE OF YOUNG STEM (TENDER) BARK OF AZADIRACHTA INDICA A. JUSS
2011
The antioxidant and hepatoprotective activity of fresh Juice of young (tender) stem bark of Azadirachta indica A. Juss, were evaluated against carbon tetrachloride (CCl4)‐induced hepatic damage in albino rats. The hepatoprotective activity of A. indica was evaluated by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP). The serum levels of total proteins and bilirubin were also estimated. Silymarin was used as standard drug. Administration of fresh juice A. indica (200 and 500 mg/kg, p.o.) markedly decrease in the elevated level of the above enzymes would indicate reversal of the induced toxicity of the liver. The perusal pharmacological assay shows that fresh juice of young stem bark extract of A. indica was good hepatotoxic agent at a dose level of 500mg/kg. the plant extract has decreased the enzyme level of SGOT, SGPT, ALP, Bilirubin by the dose of 500mg/kg and these result are statistically significant P < 0.01 when compared with CCl4 group, while juice extract increases the proteins serum level to. The results are comparable to that of silymarin as a standard. The results suggest that antioxidant and hepatoprotective effect of fresh juice of A. Indica is possible related to the free radical scavenging activity.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
20
References
6
Citations
NaN
KQI