181 Spinal deformities (SD) in young CF patients: two years experience of screening and follow up

Background: Increased survival in CF patients (pts) requires assessment of extrapulmonary morbidities, as SD. Scoliosis (S) is more frequent in CF than in general population; it causes functional spinal disorders and restrictive pulmonary disease and may be influenced by CF musculoskeletal involvement. Aims: To describe: • SD distribution in a group of CF pts • SD and clinical status relationship • 2 years follow up in a subgroup Methods: Respiratory therapist measured the angle of trunk rotation (ATR) with scoliometer in the Adams forward bending test position in CF pts, 6−19 years old (yrs). Results: 58 pts (M 46.55%, aged 12.45±3.61 yrs, median %ile for weight 39.22 and for height 49.12, mean FEV1 91.79±16.94%pred) were enrolled. No difference at baseline existed between males and females. Pts were divided in: (1) Negative group (N): ATR 0−4o (n = 48); (2) Positive group (P): ATR 5o (n = 10). Pts in P were older (p = 0.001); N had greater FVC%pred (p = 0.008). 6 thoracic (60%), 3 lumbar (30%) and 1 thoracolumbar (10%) curves (70% with right convexity) were found. Specialized physician prescribed 10 spine x-ray diagnosing S (>10o Cobb) in 3 pts (5.17%) with indication of brace. ATR correlated with height %ile (r = 0.7; p = 0.02) in P; no relationship with lung function was found. 36 pts were reassessed 2 years after the 1st evaluation. ATR was the same in 52.78% of pts, while it increased in 25%. Changes in ATR didn’t correlate with respiratory and nutritional status. Conclusion: Our data justify SD early screening and at least yearly reassessment because of their possible progression and lack of correlation with clinical data. A study to assess S and back pain prevalence in adult CF pts is ongoing. 183 Mycobacterium abscessus: stand alone hospital admission for agressive physiotherapy and nutritional review can extend periods between toxic IV antibiotic treatments J. Tame1, A. Turnbull1, J. Forton1,2. 1Noah’s Ark Children’s Hospital for Wales, University Hospital of Wales, Department of Paediatric Respiratory Medicine, Cardiff, United Kingdom; 2Cardiff University, Department of Child Health, Cardiff, United Kingdom