Impact of pazopanib on docetaxel exposure: results of a phase I combination study with two different docetaxel schedules.
2015
Purpose
There are several reasons why combining an inhibitor of the vascular endothelial and the platelet-derived growth factor receptor with a taxane might induce synergistic antitumor activity. This phase I study aimed to determine the maximal tolerated dose (MTD) of the combination of pazopanib with two different schedules of docetaxel.
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