Continuous Fabrication of Antimicrobial Nanofiber Mats Using Post-Electrospinning Functionalization for Roll-to-Roll Scale-Up
2020
The facile fabrication of antimicrobial fiber mats with surface-attached quaternary ammonium compounds (QACs) as the contact-killing antimicrobials was demonstrated. The entire process was designed to be scaled up to a continuous roll-to-roll (R2R) process using a customized R2R manufacturing platform that combines a multinozzle electrospinning technique to generate homogeneous fiber mats and a wet chemical dipping cycle with UV treatment for post-functionalization. A thiol–ene “click” reaction was used to chemically tether a QAC thiol (QAC-SH) on the surface of electrospun fibers containing an alkene functional handle (allyl-TPU). The control of the electrospinning conditions and fiber morphology was investigated by changing the solution concentrations and the tip-to-collector distance (TD). A critical solution concentration correlated to the onset of chain entanglement was necessary to obtain uniform fiber morphology. Surface functionalization of the covalently attached QAC-SH was quantified by fluoresc...
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