OXIDATIVE STRESS PARAMETERS IN ADOLESCENT BOYS WITH EXOGENOUS-CONSTITUTIONAL OBESITY

Background Child and adolescent obesity have special attention, since, it is beginning in adolescence, it is progressing and leading to the development of complications already in the adult state. One of the leading mechanisms of the pathogenesis of obesity is the activation of oxidative stress reactions, with decreased activity of antioxidant factors. Methods The state of lipid peroxidation processes in 42 adolescent boys was assessed, 19 of them were diagnosed with exogenous-constitutional obesity. Spectrophotometric and fluorometric methods were used. Results Decreased levels of primary lipid peroxidation products - diene conjugates (1.39 times) and increased concentration of secondary products - ketodienes and conjugated trienes (1.65 times) in adolescent boys with obesity were registered. In the antioxidant defense system were noted reduced values of α-tocopherol (1.42 times), retinol (1.51 times) and superoxide dismutase activity (1.19 times), in the absence of statistically significant changes in the total antioxidant activity content blood and components of glutathione status in adolescent boys with obesity in comparison with control. Conclusion Exogenous-constitutional obesity adolescent boys were exposed to more oxidative stress than adolescent boys with normal weight. Increased systemic oxidative stress induced by childhood obesity can cause development of obesity-related complications and diseases.