The Puzzle of Dietary Fat Intake and Risk of Ischemic Stroke: A Brief Review of Epidemiologic Data

Abstract While coronary heart disease (CHD) and ischemic stroke share some major risk factors, limited epidemiologic data on dietary fats and vascular disease risk indicate that ischemic stroke is affected differently by these fatty acids than is CHD. The established associations between types of fat and CHD do not appear to apply to ischemic stroke. One explanatory hypothesis for the paradoxical observations is that arteriosclerosis in different types of cerebral arteries has different causal patterns. Fatty acids or blood lipids might not be as important as other factors, such as blood pressure, in the pathogenesis of a certain type of ischemic stroke. However, confirmatory data on the associations of fatty acids and subtype of ischemic stroke, including lacunar, atherosclerotic, and cardioembolic infarction, are lacking. The purpose of this review is to summarize the epidemiologic data on dietary fat and fatty acids in relation to ischemic stroke. Future investigations are needed to examine the effects of fatty acids on subtype of ischemic stroke and to clarify the possible differences of dietary fat in relation to ischemic stroke and CHD.