1,2,3,4-tetrahydroquinolines 2-substituted 4-amino substituted as CETP inhibitors.

A compound of the formula ** ** or a pharmaceutically acceptable salt thereof; wherein R1 is Y, WX or WY; where W is carbonyl, thiocarbonyl, sulfinyl or sulfonyl; X is -OY, -SY, -N (H) -Y or -N- (Y) 2; wherein Y for each occurrence is independently Z or a straight or branched carbon chain of one to ten membered, fully saturated, partially unsaturated or fully unsaturated wherein the carbons other than the connecting carbon, may optionally be replaced with one or two heteroatoms selected independently from oxygen, sulfur and nitrogen and said carbon is optionally mono-, di- or tri- substituted independently with halo, said carbon is optionally mono-substituted with hydroxy, said carbon is optionally mono-substituted with oxo, said sulfur is optionally mono- or di-substituted with oxo, said nitrogen is optionally mono- or di- substituted with oxo, and said carbon chain is optionally mono-substituted with Z; wherein Z is a ring of three to eight partially saturated, fully saturated or fully unsaturated members optionally having one to four heteroatoms selected independently from oxygen, sulfur and nitrogen, or a bicyclic ring consisting of two fused three to six members partially saturated, fully saturated or fully unsaturated, taken independently, optionally having one to four heteroatoms independently selected from nitrogen, sulfur and oxygen.