Maculopapular eruptions associated to COVID-19: a subanalysis of the COVID-Piel study.

BACKGROUND: A previous study has defined the maculopapular subtype of manifestations of COVID-19. OBJECTIVES: To describe and classify maculopapular eruptions associated with COVI-19. METHODS: We carried out a subanalysis of the maculopapular cases found in the previous cross-sectional study. Using a consensus, we defined 7 clinical patterns. We described patient demographics, the therapy received by the patient and the characteristics of each pattern. RESULTS: Consensus lead to the description of 7 major maculopapular patterns: Morbilliform (45.5%), Other maculopapular (20.0%), Purpuric (14.2%), Erythema multiforme-like (9.7%), Pytiriasis rosea-like (5.7%), Erythema elevatum diutinum-like (2.3%) and Perifollicular (2.3%). In most cases, maculopapular eruptions were coincident (61.9%) or subsequent (34.1%) to the onset of other COVID-19 manifestations. The most frequent were cough (76%), dyspnea (72%), fever (88%), and astenia (62%). Hospital admission due to pneumonia was frequent (61%). Drug intake was frequent (78%). Laboratory alterations associated with maculo-papular eruptions were high C-reactive protein, high D-Dimer, lymphopenia, high ferritin, high LDH, and high IL-6. LIMITATIONS: The impossibility to define the cause-effect relationship of each pattern. CONCLUSION: We provide a description of the cutaneous maculopapular manifestations associated with COVID-19. The cutaneous manifestations of COVID-19 are wide-ranging and can mimic other dermatoses. This article is protected by copyright. All rights reserved.