Lumbar myelography with iopamidol: A methodological approach to the investigation of side effects

Pathophysiology of adverse reactions occurring during myelography with non-ionic contrast agents, such as iopamidol, seem related to their direct action on the nervous system. The authors try a multivariate approach, involving neurophysiological, neuropsychological and neurochemical parameters on a pilot group of twelve subjects. Any possible change in the above examinations is throughly analyzed and correlated to the postulated neurotoxic properties of contrast media.