Combinatorial synthesis of peptide arrays with a laser printer

however, thedecodingofpeptidebindersislaborintensive.Furthermore,problematicpeptides,forexample,hydrophobicpeptidesthatbind nonspecifically to any protein, are also synthesizedduringlibrarypreparationbythesemethods.Arrays do not have these drawbacks. The position of agivenpeptideonanarraycorrespondsdirectlytoitssequence,and problematic peptides can be omitted in subsequentarrays. Peptide arrays were first described by Frank, whosespotsynthesisdominatesthefieldbecauseofitsreliabilityandwideapplicability.