Study of the expression of cathepsins in histological material from pancreatic lesions
2016
Background and aims: To assess the expression levels of
cathepsins in malignant and premalignant lesions.
Methods: We retrospectively included patients who underwent
pancreatic surgery on pancreatic solid or cystic masses. The expression
of cathepsin H, L, B and S was determined in both types
of samples. Lesions were divided into three categories: malignant
(pancreatic adenocarcinoma and malignant mucinous neoplasms),
premalignant (mucinous neoplasms) and benign (other lesions).
Results: Thirty-one surgical resection samples were studied.
The expression of cathepsins was significantly higher in malignant
lesions than in premalignant and benign lesions (H 75%, 27%, 37%
p = 0.05; L 92%, 36%, 37% p = 0.011; B 83%, 36%, 62% p =
0.069; S 92%, 36%, 25% p = 0.004, respectively).
Conclusions: Cathepsins are overexpressed in histological
samples of malignant lesions compared to premalignant and benign
lesions. However, the expression of cathepsins is similar in both
premalignant and benign lesions.
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