Tiroid Nodüllerinde Malign ve Benign Ayrımında Difüzyon Ağırlıklı Manyetik Rezonans İncelemenin Yeri

Oz Amac: Bu calismanin amaci, Difuzyon Agirlikli Manyetik Rezonans Goruntulemenin (DAMRG) tiroid nodullerinde malign-benign ayrimindaki yerini arastirmak olacaktir. Material-Metot: Calismaya tiroid nodulu ve patolojik tanisi olan 39 hasta ve 40 nodul dahil edildi. Izlenen noduller, DAMRG ile incelendi ve elde edilen Apparent Diffusion Coefficient (ADC) degerleri ve patolojik sonuclar arasindaki iliski istatistiksel olarak degerlendirildi. Bulgular: Nodullerin 9’u malign, 31’i benign karakterdeydi. Malign ve benign nodullerin ortalama ADC degerleri sirasiyla (1,60±0,29)x10 ⁻ ³ sn/mm²)ve (2,14±0,39)x10 ⁻ ³ sn/mm²) bulundu. Malign ve benign ADC degerleri arasinda anlamli istatistiksel farklilik izlendi (p<0,001). Receiver Operator Coefficient (ROC) analizi ile malign nodullerde cut-off deger 1,67x10 ⁻ ³ sn/mm² olarak hesaplandi. Sonuc: ADC degerleri , benign ve malign tiroid nodullerini ayirmak icin non-invaziv bir tani metodu olarak kullanilabilir. Abstract Objective: The aim of this study was to investigate the role of the Diffusion Weighted Imaging (DWI) sequences of Magnetic Resonance Imaging (MR) in diagnosis of malignant and benign nodules of thyroid nodules. Matherial/Method: Thirty nine patients and fourty nodules were enrolled to the study. The observed nodules were examined with DWI. Relationship between obtained Apparent Diffusion Coefficient (ADC) values and pathological results were statistically evaluated. Results: There were 9 malignant and 31 benign nodules. Mean ADC values were evaluated (1.60±0.29)x10 ⁻ ³ sn/mm² for malignant nodules , and (2.14±0.39)x10 ⁻ ³ sn/mm²) for benign nodules, respectively. There was a statistical difference between ADC values of malignant and benign nodules (p<0.001). The ADC cut-off value of malignant nodules was evaluated 1.67x10 ⁻ ³ sn/mm² with Receiver Operator Coefficient (ROC) analysis. Conclusion: ADC values might be used as a non-invasive diagnostic tool for discriminating the malignant and benign thyroid nodules.